Molecular Mechanisms of Insulin Resistance Development
نویسندگان
چکیده
منابع مشابه
[Molecular Mechanisms of Insulin Resistance: An Update].
The biological actions of insulin are initiated by activating its membrane receptor, which triggers multiple signaling pathways to mediate their biological actions. Due to the importance of metabolic regulation and promoting functions of cell growth and proliferation, insulin actions are highly regulated to promote proper metabolic functioning and energy balance. If these mechanisms are altered...
متن کاملMolecular Mechanisms of Insulin Resistance in Chronic Kidney Disease
Insulin resistance refers to reduced sensitivity of organs to insulin-initiated biologic processes that result in metabolic defects. Insulin resistance is common in patients with end-stage renal disease but also occurs in patients with chronic kidney disease (CKD), even when the serum creatinine is minimally increased. Following insulin binding to its receptor, auto-phosphorylation of the insul...
متن کاملMolecular mechanisms of insulin resistance that impact cardiovascular biology.
Insulin resistance is concomitant with type 2 diabetes, obesity, hypertension, and other features of the metabolic syndrome. Because insulin resistance is associated with cardiovascular disease, both scientists and physicians have taken great interest in this disorder. Insulin resistance is associated with compensatory hyperinsulinemia, but individual contributions of either of these two condit...
متن کاملMolecular Mechanisms of Insulin Resistance in Chronic Liver Disease
Index 1. Introduction 6 1.1. Hepatitis C Virus Infection 6 Epidemiology and natural history of hepatitis C 6 The Hepatitis C Virus 6 Insulin Resistance in chronic hepatitis C 7 1.2. Non alcoholic fatty liver disease (NAFLD) 8 1.3. Overexpression of PP2Ac in chronic hepatitis C 8 Interferon (IFN) signaling is inhibited in chronic hepatitis C 8 Protein Phosphatase 2A (PP2A) 8 Upregulation of PP2A...
متن کاملMolecular mechanisms involved in multidrug resistance in breast cancer therapy
Breast cancer is the most prevalent cancer in women. Chemotherapy is the main strategy in the treatment of this disease especially in the advanced form of the disease. Despite the recent progress in the development of new chemotherapy, the effectiveness of these drugs has dramatically reduced due to multidrug resistance. The phenotype of multidrug resistance (MDR) can occur through different me...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diabetes mellitus
سال: 2014
ISSN: 2072-0378,2072-0351
DOI: 10.14341/dm2014229-40